4.6 Article

Copper-catalyzed formation of N,N-dimethyl benzamide from nitrile and DMF under an O2 atmosphere

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 47, Pages 8179-8182

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41855c

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Funding

  1. Natural Science Foundation of China [21072132, 21272161, 21372163, J1103315]
  2. Ministry of Education of China [20120181110050]

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Amidation of nitrile with N,N-dimethylformamide (DMF) was catalyzed by Cu2O with 1,10-phenanthroline as a ligand under an oxygen atmosphere. A variety of N,N-dimethyl benzamides were obtained in yields up to 84%.

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