Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 35, Pages 5885-5891Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41170b
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- CEA
- Les Laboratoires Pierre Fabre
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The syntheses of 20,20-difluorocatharanthine and congeners, starting from the naturally occurring catharanthine, are reported. The fluorinated catharanthine analogues were investigated as potential precursors to dimeric Vinca alkaloids of the vinflunine family. However, the biomimetic coupling of the fluorinated catharanthine derivatives with vindoline led to unexpected alkaloid structures, the formation of which was rationalized.
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