Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 16, Pages 2586-2596Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27209e
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Funding
- Ministerio de Ciencia e Innovacion [CTQ2011-29299-CO2-01]
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The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene-sugar, ferrocene-cyclodextrin, ferrocene-peptide and ferrocene-protein conjugates).
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