4.6 Article

An expedient stereoselective and chemoselective synthesis of bicyclic oxazolidinones from quinols and isocyanates

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 18, Pages 2939-2942

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob00047h

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Funding

  1. Hunter College
  2. PSC-CUNY
  3. Bertha and Louis Weinstein Research Grant
  4. Molecular Design Institute at the Department of Chemistry of New York University

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A mild and efficient synthesis of bicyclic oxazolidinones from quinols and isocyanates, under DBU-mediated conditions at room temperature, is described. The aza-Michael addition to substituted cyclohexadienones is stereoselective and chemoselective.

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