Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 11, Issue 8, Pages 1280-1285Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob27321k
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- CSIR, New Delhi
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The HKR of racemic anti- or syn-3-substituted epoxy esters catalyzed by a Co(III)salen complex provides ready access to the corresponding enantioenriched 3,4-disubstituted gamma-butyrolactones and 3-substituted epoxy esters. This strategy has been successfully employed in the formal synthesis of biologically active 3,4-disubstituted piperidine derivatives, (-)-paroxetine and Ro 67-8867 and a natural product, (+)-eldanolide.
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