4.6 Article

Ruthenium-catalysed oxidative synthesis of heterocycles from alcohols

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 2, Pages 240-243

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06516e

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Funding

  1. GlaxoSmithKline
  2. Pfizer
  3. AstraZeneca
  4. Novartis
  5. EPSRC

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Ruthenium-catalysed hydrogen transfer has been successfully used for the conversion of alcohols into either 2,3-dihydroquinazolines or quinazolines. The choice of reaction conditions allows for the selective formation of either heterocycle and the methodology can also be applied to the sulfonamide analogue.

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