4.6 Article

A copper-based catalytic system for carboxylation of terminal alkynes: synthesis of alkyl 2-alkynoates

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 8, Pages 1514-1516

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob06884b

Keywords

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Funding

  1. Japan Society for the Promotion of Science [23390002, 23659001, 23790002]
  2. Grants-in-Aid for Scientific Research [23390002, 23790002, 23659001] Funding Source: KAKEN

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An efficient coupling of terminal alkynes and CO2 in the presence of alkyl halides can be achieved under ambient conditions using a copper/phosphine catalyst system, providing facile access to a variety of functionalised alkyl 2-alkynoates.

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