4.6 Article

Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 35, Pages 7177-7183

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26139a

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2009CB825300]
  2. National Natural Science Foundation of China [21025209, 20932008, 21102160, 21121062]
  3. Chinese Academy of Sciences

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Lewis acid-catalyzed cascade dearomatization of N-substituted tryptophols via Michael addition reaction was developed. The generality of the method has been demonstrated by the synthesis of versatile furoindoline derivatives with a quaternary carbon center in good yields.

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