4.6 Article

Highly selective, naked-eye and fluorescent off-on probe for detection of histidine/histidine-rich proteins and its application in living cell imaging

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 8, Pages 1653-1658

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob06520g

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB126100]
  2. National High Technology Research and Development Program of China (863 Program) [2011AA10A207]
  3. National Natural Science Foundation of China [21076077]
  4. China 111 Project [B07023]
  5. Shanghai Leading Academic Discipline [B507]
  6. Fundamental Research Funds for the Central Universities

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A highly selective colorimetric and fluorescence enhanced probe S1 (M2@Cu) for histidine and histidine-rich proteins has been developed. In neutral aqueous ethanol solution, probe S1 can selectively detect histidine out of twenty DNA encoded amino acids by showing a color change from brownish red to light green, and with a fluorescence enhancement up to 99-fold at 537 nm, simultaneously.

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