4.6 Article

Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 13, Pages 2537-2541

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25075f

Keywords

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Funding

  1. National University of Singapore
  2. Singapore Ministry of Education [R143000408133, R143000408733, R143000443112, R143000480112, NRF-CRP7-2010-03]

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3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).

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