Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 7, Pages 1374-1380Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06500a
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Funding
- Ministry of Health, Labour and Welfare [20100201]
- Ministry of Education, Science, Sports, Culture and Technology from Japan [23390018]
- Grants-in-Aid for Scientific Research [23390018, 22591605, 22790113, 23390013] Funding Source: KAKEN
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The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent intensities of the FL-SBL-labeled DSPC liposomes increased with the increase of the additive FL-SBL, and the maximum emission wavelength of the liposomes appeared at 531 nm. A preliminary in vivo imaging study of tumor-bearing mice revealed that the FL-SBL-labeled DSPC liposomes were delivered to the tumor tissue but not distributed to hypoxic regions.
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