4.6 Article

Copper-catalyzed domino coupling reaction: an efficient method to synthesize oxindoles

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 31, Pages 6404-6409

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26110c

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Funding

  1. National Science Council of the Republic of China [NSC-99-2113-M-032-003-MY2]

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An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields.

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