4.6 Article

Iminosugar-ferrocene conjugates as potential anticancer agents

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 29, Pages 5592-5597

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25727k

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Funding

  1. Ministry of Higher Education and Research (MESR)
  2. CNRS
  3. Conseil Regional Champagne Ardenne
  4. Conseil General de la Marne
  5. EU

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We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation of a 2-ethanalylpyrrolidine.

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