Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 1, Pages 90-95Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06630g
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- Grants-in-Aid for Scientific Research [22655033, 22750107] Funding Source: KAKEN
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We report that a polyhedral oligomeric silsesquioxane (POSS) core in a dendrimer can enhance the affinity of the molecular recognition via hydrogen bonds between 1,8-naphthyridine and guanosine nucleotides. The complexation of the naphthyridine ligands with a series of guanosine nucleotides was investigated, and it is shown that the POSS core should play a significant role in the stabilization of the complexes via hydrogen bonds. Finally, we demonstrate that the 1,8-naphthyridine ligand can selectively recognize guanosine triphosphate by assisting with the POSS-core dendrimer.
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