Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 13, Pages 2656-2663Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob06747a
Keywords
-
Categories
Funding
- University of Queensland (UQ/IMB)
- Institute for Molecular Bioscience, University of Queensland
- University of Queensland
- Australian Research Council [LP0775547]
- Australian Research Council [LP0775547] Funding Source: Australian Research Council
Ask authors/readers for more resources
Fractionation of a southern Australian marine sponge, Ianthella sp., yielded sixteen metabolites including a new class of pyrrolidone, ianthellidones A-F (1-6), a new class of furanone, ianthellidones G-H (7-8), new and known lamellarins, lamellarins O1 (9), O2 (10), O (11) and Q (12), plus the known 4-hydroxybenzaldehyde (13), 4-hydroxybenzoic acid (14), 4-methoxybenzoic acid (15) and ethyl 4-hydroxybenzoate (16). Structures for all Ianthella metabolites were determined by detailed spectroscopic analysis, supported by a plausible biosynthetic relationship. The ianthellidones were non-cytotoxic towards two human colon cancer cell lines (SW620 and SW620 Ad300), as well as Gram +ve and Gram -ve bacteria, and a fungus. Ianthellidone F (6) and lamellarins O2 (10) and O (11) displayed modest BACE inhibitory properties (IC50 > 10 mu M), while lamellarin O1 (9) was more potent (IC50 < 10 mu M). Lamellarin O (11) exhibited modest cytotoxicity towards SW620 and SW620 Ad300 cell lines (IC50 > 22 mu M), was an inhibitor of the multi-drug resistance efflux pump P-glycoprotein, and displayed selective growth inhibitory activity against the Gram +ve bacterium Bacillus subtilis (ATCC 6633) (IC50 2.5 mu M).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available