Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 44, Pages 8911-8918Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26596f
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- University of Sydney
- UNSW
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Backbone-fluorinated amino acids exhibit unique conformational behaviour, and have potential utility as components of bioactive shape-controlled peptides. However, methods for the elaboration of backbone-fluorinated amino acids have thus far been limited to solution phase peptide coupling reactions. In this paper, protocols are developed that allow the successful manipulation of backbone-fluorinated amino acids using Fmoc-strategy solid phase peptide synthesis. To exemplify this strategy, several fluorinated RGD peptide analogues were synthesised in moderate to good overall yields.
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