4.6 Article

A seminaphthofluorescein-based fluorescent chemodosimeter for the highly selective detection of cysteine

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 14, Pages 2739-2741

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25178g

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Funding

  1. National Institutes of Health [RO1 EB002044]
  2. China Scholarship Council
  3. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB002044] Funding Source: NIH RePORTER

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A fluorescent chemodosimeter for cysteine detection was developed based on a tandem conjugate addition and intramolecular cyclization reaction. The method exhibited an excellent selectivity for cysteine over other biothiols such as homocysteine and glutathione.

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