Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 26, Pages 5039-5044Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25192b
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- Science and Technology Department of Guiyang [(2008) 36]
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Phytochemical study of the leaves of the medicinal plant Isodon rubescens led to the isolation of three novel abietane diterpenoids, rubesanolides C-E (1-3). These diterpenes contain a unique.-lactone subgroup formed between C-8 and C-20. Their structures were determined from analysis of spectroscopic data, and were further confirmed by X-ray crystallographic data. The compounds were evaluated for their antibacterial activity, and rubesanolide D (2) demonstrated inhibition activity against biofilm formation of the dental bacterium Streptococcus mutans.
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