Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 41, Pages 8322-8325Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26248g
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Funding
- Robert A. Welch Foundation [T-1460]
- National Science Foundation [CHE-1213287]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1213287] Funding Source: National Science Foundation
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A new type of pyrrolidine-based organocatalyst, which was developed earlier in our lab, has been found to be very effective for the Michael addition reaction in aqueous solvents involving a wide range of alpha,beta-unsaturated aldehydes and malonate derivatives. For the reactions studied, good to excellent yields (73%-96%) and high to excellent enantioselectivities (up to 97%) were obtained using this catalyst. In addition, the catalyst could be recycled up to four times with gradual reductions in yields and enantioselectivity observed after the second cycle.
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