Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 35, Pages 7098-7102Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25875g
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Funding
- State Ethnic Affairs Commission
- Key Laboratory of Ethnic Medicine Resource Chemistry [MZY 1117]
- Yunnan University of Nationalities [09QN04]
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A new procedure is developed for the synthesis of alpha-aminophosphonates containing thiazole[5,4-b]pyridine moiety from conveniently available starting materials. The target compounds were characterized by infrared, H-1 NMR, C-13 NMR, P-31 NMR, mass spectrometry and elemental analysis. The newly synthesized compounds were evaluated for their anticancer activities against PC-3, Bcap-37, H460 cells in vitro by the MTT method. Compounds 3b and 3f are highly effective against PC-3, Bcap-37 cells and good to H460 cells. Further study is necessary to find out the potential antitumor activities.
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