4.6 Article

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatinand its 2-epi and 2,4-diepi analogues

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 4, Pages 825-834

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06374j

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Funding

  1. Ministry of Science and Innovation [CTQ2008-03253]
  2. Xunta de Galicia [08CSA046209PR, 2007/XA084]
  3. Diputacion de A Coruna

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A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (+/-)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.

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