Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 35, Pages 7108-7119Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25643f
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- Science Technology Department of Zhejiang Province [2012R10014-15]
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New transition metal-catalyzed methods for the arylation of indolizines by the direct cleavage of C-H bonds have been developed. A wide range of aryltrifluoroborate salts react with indolizines in the presence of Pd(OAc)(2) catalyst and AgOAc oxidant to give the arylated indolizines in high yields. Both electron-donating and electron-withdrawing groups perform smoothly while bromide and chlorine substituents are tolerated. In addition, the indolizines display similar reactivities in the Pd-catalyzed reaction with 3-phenylpropiolic acid to afford the corresponding C-3 alkynylated indolizines. These methods allow the direct functionalization of indolizines in one step.
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