4.6 Article

A highly active catalytic system for Suzuki-Miyaura cross-coupling reactions of aryl and heteroaryl chlorides in water

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 47, Pages 9410-9417

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26463c

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Funding

  1. National Natural Science Foundation of China [21072071, 20931006, 21072070]
  2. Program for Changjiang Scholars and Innovative Research Team in University [IRT0953]
  3. Program for Academic Leader in Wuhan Municipality [201271130441]
  4. Science Foundation of Central China Normal University

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An easily available Pd(OAc)(2)/(2-mesitylindenyl)dicyclohexylphosphine/Me(octyl)(3)N+Cl-/K3PO4 center dot 3H(2)O catalytic system was developed and it shows high catalytic activity in the Suzuki-Miyaura cross-coupling reaction of a diverse array of aryl and heteroaryl chlorides in water. Notably, this catalytic system also works with ultra-low loading of the catalyst with high turnover numbers.

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