4.6 Article

Efficient synthesis of N-(buta-2,3-dienyl) amides from terminal N-propargyl amides and their synthetic potential towards oxazoline derivatives

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 42, Pages 8465-8470

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob26291f

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Funding

  1. Major State Basic Research Development Program [2009CB825300]

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A series of N-allenyl amides was prepared conveniently from N-propargyl amides in good to excellent yields via a modified procedure developed in this group. The palladium-catalyzed coupling-cyclization of these prepared N-allenyl amides in the presence of organic iodides has been developed affording the oxazoline derivatives efficiently.

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