Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 10, Issue 30, Pages 5760-5763Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob25900a
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Funding
- EPSRC [EP/D060192/1]
- Commonwealth Commission
- Engineering and Physical Sciences Research Council [EP/D060192/1] Funding Source: researchfish
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Synthetic lectins are molecules designed for the challenging task of biomimetic carbohydrate recognition in water. Previous work has explored a family of such systems based on bi/terphenyl units as hydrophobic surfaces and isophthalamide spacers to provide polar binding groups. Here we report a related receptor which employs a new spacer, 2,5-bis-(aminomethyl)-pyrrole, with an alternative (A-D-A) set of H-bonding valencies. The modified spacer leads to significant changes in binding selectivity, including a preference for glucose over all other tested substrates.
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