Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 5, Pages 1320-1323Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01069c
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Funding
- EPSRC [EP/E052789/1]
- Engineering and Physical Sciences Research Council [EP/E052789/1] Funding Source: researchfish
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Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via transamidation.
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