Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 1, Pages 278-290Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00396d
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Funding
- Wellcome Trust [084068]
- MRC
- Deutsche Forschungsgemeinschaft
- Gemeinnutzige Hertie-Stiftung
- Deutsche Akademische Austauschdienst
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Novel 8-substituted base and sugar-modified analogues of the Ca2+ mobilizing second messenger cyclic adenosine 5'-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by H-1 NMR spectroscopy revealed that a C2' endo/syn conformation of the southern ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.
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