Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 9, Pages 3349-3358Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob00017a
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Funding
- National Basic Research Program of China (973) [2010CB833302]
- Fundamental Research Funds for the Central Universities
- National Natural Science Foundation of China [21072206, 20472096, 20902019, 20872162, 20672127, 20821002, 20732008, 20772030, 20702059]
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Multifunctional chiral phosphine (phosphine-thiourea type) L2-catalyzed allylic substitutions of MBH adducts 1 with oxazolones 2 produce the corresponding optically active adducts 3 in good to excellent yields and ee's as well as moderate to good de's under mild conditions. The synergistic interaction between hydrogen bond donor site and nucleophilic site has been discussed, indicating that finely tuning the active sites of the multifunctional phosphine organocatalysts is very important.
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