Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 13, Pages 4760-4762Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05519d
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Funding
- A*STAR (Agency for Science, Technology and Research, Singapore)
- Biomedical Research Council
- A*STAR SSCC [SSCC10/024]
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We report the synthesis and characterization of a novel NIR fluorescent deoxyglucose analogue, CyNE 2-DG. Experiments in different cell lines showed a preferential uptake of CyNE 2-DG in cancer cells and its effective competition with unlabeled D-glucose. Cell imaging experiments demonstrated the superior cell-permeability of CyNE 2-DG over the NIR standard IRDye 800CW 2-DG, and validated its application for cancer cell imaging in the NIR region.
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