4.6 Article

Asymmetric construction of 3-vinylidene-pyrrolidine derivatives containing allene moiety via Ag(I)/TF-BiphamPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with diethyl 2-(3,3-diphenylpropa-1,2-dienylidene) malonate

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 10, Pages 3622-3624

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05291h

Keywords

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Funding

  1. National Natural Science Foundation of China [20702039, 20972117, 2011CB808600, 20090141110042]
  2. Fundamental Research Funds for the Central Universities

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Catalytic asymmetric 1,3-dipolar cycloaddition of various azomethine ylides with diethyl 2-(3,3-diphenylpropa-1,2-dienylidene) malonate has been developed successfully with good to excellent enantioselectivity for the effcient construction of 3-vinylidene-pyrrolidine derivatives containing a unique allene moiety.

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