Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 4, Pages 1118-1125Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00467g
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Funding
- Proyecto de Excelencia of the Consejeria de Innovacion [P08-FQM-3596]
- Ciencia y Empresa
- Junta de Andalucia
- CYTED [IV. 12]
- Spanish Ministry of Science and Technology [BQU 200203211]
- Alban Programme [N. E04D041998AC]
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Highly efficient preparations of anticancer beta-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described
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