Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 13, Pages 4921-4926Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01188f
Keywords
-
Categories
Ask authors/readers for more resources
A conjugation of bile acids with peptides via Cu(I)-catalyzed click chemistry has been described. Novel bile acid-peptide conjugates linked via a 1,2,3-triazole moiety based on cholic, deoxycholic and lithocholic acid derivatives were synthesized using Cu(I)-catalyzed 1,3-dipolar cycloaddition (click reaction). It was shown that up to three peptide fragments can be attached to a central steroid core, thus forming complex three-dimensional polyconjugate structures, which can find important applications in biochemistry, medicinal chemistry, and coordination chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available