Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 10, Pages 3691-3697Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05404j
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Funding
- National University of Singapore [R143000408133, R143000408733, R143000443112]
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An efficient, convenient and enantioselective Michael-hemiketalization reaction has been developed for the synthesis of naphthoquinones. In this work, a novel trans-bifunctional indane thiourea catalyst has been reported to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (90-98% ee).
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