Chiral indane skeleton based thiourea catalyzed highly stereoselective cascade Michael-enolation-cyclization reaction

An efficient asymmetric cascade reaction catalyzed by a chiral bifunctional indane amine-thiourea catalyst has been developed. From a broad substrate scope, chiral dihydro-2H-pyran complexes that contained two stereogenic centers were obtained in a one-pot manner in good to excellent yields (72-97%) and high to excellent stereoselectivities (92-97% ee).