4.6 Article

One-pot synthesis of pyrrolo[1,2-a]quinoxalines

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 21, Pages 7351-7357

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05936j

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Funding

  1. National Science Foundation of China [20872079]
  2. Natural Science Foundation of Shandong Province [2009ZRB019YA]
  3. State Key Laboratory of Natural and Biomimetic Drugs of Peking University [K20090205]

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A transition metal-free process for the regioselective synthesis of pyrrolo[1,2-a]quinoxalines under mild conditions in one-pot is described. The reaction afforded a variety of products in good to excellent yields. Indolo[1,2-a] quinoxalines were also synthesized from indole-2-carboxamides under the same conditions.

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