4.6 Article

Structure-activity studies of the pelorusides: new congeners and semi-synthetic analogues

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 12, Pages 4456-4466

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob01127d

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Funding

  1. Foundation for Research, Science & Technology (FRST)
  2. Curtis-Gordon Research Scholarship in Chemistry
  3. Tertiary Education Commission of New Zealand
  4. Wellington Medical Research Foundation
  5. VUW

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Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.

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