Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 18, Pages 6331-6334Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05576c
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- BMBF (Bundesministerium fur Bildung und Forschung)
- Deutsche Forschungsgemeinschaft (Leibniz-price) [GRK 1113]
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A general synthesis of 3-amidoindoles from easily available arylhydrazines and acylated propargylamines is described. In the presence of inexpensive Zn salts, alkyne amination and subsequent Fischer indole-cyclization took place in good yields with excellent regioselectivity providing an interesting scaffold for potentially bio-active compounds.
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