4.6 Article

Ready access to 3-amino-2,3-dideoxysugars via regio- and stereo-selective tandem hydroamination-glycosylation of glycals

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 10, Pages 3929-3939

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05068k

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Funding

  1. Nanyang Technological University [RG50/08]
  2. Ministry of Education, Singapore [MOE 2009-T2-1-030]

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A highly stereoselective BF3 center dot OEt2-promoted tandem hydroamination-glycosylation on a glycal scaffold has been developed to form 3-amino-2,3-dideoxysugars in a one-pot procedure. This efficient multicomponent reaction protocol offers simplicity and general applicability to a broad range of variations on each component.

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