Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 19, Pages 6623-6628Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05835e
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Funding
- University of Geneva
- University of Basel
- European Research Council (ERC Advanced Investigator)
- National Centre of Competence in Research (NCCR) Chemical Biology
- NCCR Nanosciences
- Swiss NSF
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Transport across the membranes of polymersomes remains difficult in part due to the great thickness of the polymer bilayers. Here, we report that dynamic polyion-counterion transport systems are active in fluorogenic polymersomes composed of poly(dimethylsiloxane)-b-poly(2-methyloxazoline) (PDMS-PMOXA). These results suggest that counterion-activated calf-thymus DNA can act as cation carrier that moves not only across lipid bilayer and bulk chloroform membranes but also across the plastic membranes of polymersomes. Compared to egg yolk phosophatidylcholine (EYPC) lipsosomes, activities and activator scope in PDMS-PMOXA polymersomes are clearly reduced. Embedded in agar gel matrices, fluorogenic PDMS-PMOXA polymersomes respond reliably to polyion-counterion transporters, with high contrast, high stability and preserved selectivity. Compared to standard EYPC liposomes, it cannot be said that PDMS-PMOXA polymersomes are better. However, they are different, and this difference could be interesting for the development of sensing devices.
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