4.6 Article

Synthesis of (1R,2R)-DPEN-derived triazolium salts and their application in asymmetric intramolecular Stetter reactions

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 7, Pages 2072-2074

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob00025j

Keywords

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Funding

  1. National Natural Science Foundation of China [20732006, 20821002, 20972177, 21025209]
  2. National Basic Research Program of China (973 Program) [2009CB825300]

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A series of novel chiral triazolium salts has been synthesized from readily available (1R,2R)-DPEN and found to be efficient for the enantioselective intramolecular Stetter reaction. With 10 mol% of the catalyst, the intramolecular Stetter reaction was realized in excellent yields with up to 97% ee.

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