4.6 Article

Novel one-pot process for the synthesis of 1,3-thiazoles via organocatalysed epoxidation of nitro-olefins

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 9, Pages 3457-3461

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05260h

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Funding

  1. Deutsche Forschungsgemeinschaft [1179]
  2. BMBF [MDA 08/010]

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A facile one-pot two-step process for the synthesis of 1,3-thiazole heterocycles via organocatalytic epoxidation of nitro-olefins with the t-BuOOH/DBU system, and subsequent reaction of alpha-nitro-epoxides with thioamides under mild conditions has been developed.

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