4.6 Article

Asymmetric organocatalytic Michael-alpha-amination sequence for the construction of a quaternary stereocenter

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 4, Pages 994-997

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00751j

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Funding

  1. MENRT
  2. CNRS
  3. University of Versailles-St-Quentin-en-Yvelines

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Combination of secondary and primary amine-catalyzed organocascade Michael-alpha-amination is described. This sequence afforded alpha-hydrazino aldehydes bearing a quaternary stereocenter with high yield and excellent stereoselectivity.

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