Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 3, Pages 834-844Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00351d
Keywords
-
Categories
Funding
- National Museum of Marine Biology Aquarium [NMM98001]
- National Science Council of Taiwan [NSC-98-2113-M-110-002-MY3]
- Ministry of Education of Taiwan [98C031702]
Ask authors/readers for more resources
New eunicellin-base diterpenoids, klysimplexins I-T (1-12), were isolated from a cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute stereochemistry of 4 was determined by Mosher's method. Compounds 9 and 12 have been shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Compounds 2-6, 10 and 11 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds 10 and 11 also could effectively reduce the level of COX-2 protein.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available