Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 6, Pages 1791-1798Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00725k
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Funding
- National Natural Science Foundation of China [20972076, 20772061]
- Natural Science Foundation of Tianjin [10JCYBJC04000]
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A novel NHC-catalyzed three-component domino strategy to access high functionalized cis-epsilon-ketoesters with excellent yields (up to 98%) and high stereoselectivities (up to 20 : 1) is documented. The title domino reactions are atom economical and work on a broad range of substrates. The relative stereochemistry could be explained by a cascade crossed-benzoin/oxy-Cope rearrangement/esterification process. The thus-obtained products are of potential synthetic value in the drug research and combinatorial chemistry.
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