Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 5, Pages 1328-1331Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00886a
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Funding
- CRUK [C129/A10902]
- Cancer Research UK [6950] Funding Source: researchfish
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Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analogue, and with a different binding mode involving reversal of the pyrrolidinium N+-H orientation.
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