Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 20, Pages 6903-6908Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06017a
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Funding
- Georganics Ltd
- German Academic Exchange Service DAAD
- Sanofi-Aventis
- CSIRO Material Science and Engineering
- EPSRC
- Royal Society
- [BP 1702]
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
- EPSRC [EP/F069685/1] Funding Source: UKRI
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We report on the development of a continuous flow process for the palladium catalysed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of carbon monoxide into solution at elevated pressures. The low volume of pressurised gas within the reactor (5.6 mL) offers the potential for an enhanced safety profile compared to batch processes. We also present preliminary results for the use of in situ FTIR to measure solution concentrations of carbon monoxide and demonstrate the use of a second reactor to effect the removal of carbon monoxide from the flow stream.
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