Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 22, Pages 7629-7632Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob06009k
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Funding
- Spanish grants [SAF2010-20822-C02, SAF2010-15512]
- Consolider-Ingenio [CSD2007-00006]
- Xunta de Galicia [INCITE09209084PR, GRC2010/12]
- ERDF
- Spanish MEC
- [CTQ2009-14431]
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We report the design and development of a fluorescent sensor specifically designed to target cyclin A, a protein that plays a key role in the regulation of the cell cycle. Computational studies provide a molecular picture that explains the observed emission increase, suggesting that the 4-DMAP fluorophore in the peptide is protected from the bulk solvent when inserted into the hydrophobic binding groove of cyclin A.
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