Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 9, Issue 17, Pages 5945-5947Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1ob05766a
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- Australian Research Council
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Using structural insight, the binding mode of isofagomine-derived inhibitors with family GH9 glycosidases is achieved via the study of Alicyclobacillus acidocaldarius (AaCel9A) endoglucanase. In contrast to what was observed in the first report using these compounds with inverting glycosidases from family GH6, these inhibitors do not adopt a distorted conformation in the active site.
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