Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 12, Pages 2771-2776Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c002418j
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Funding
- BBSRC
- Cancer Research UK
- Cambridge Commonwealth Trust
- Trinity College, Cambridge
- Netherlands Ramsay Memorial Fellowship
- Human Frontier Long-term Fellowship [LT0798/2005]
- BBSRC [BB/G008337/1, BB/E019773/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E019773/1, BB/G008337/1] Funding Source: researchfish
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Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
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