Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 8, Issue 10, Pages 2344-2351Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c001164a
Keywords
-
Categories
Funding
- Engineering and Physical Sciences Research Council [EP/D077842/1, EP/G022569/1]
- European Research Council [240342]
- EPSRC [EP/G022569/1, EP/D077842/1] Funding Source: UKRI
Ask authors/readers for more resources
Generic approaches for the design and synthesis of small molecule inhibitors of protein-protein interactions (PPIs) represent a key objective in modern chemical biology. Within this context, the alpha-helix mediated PPIs have received considerable attention as targets for inhibition using small molecules, foldamers and proteomimetics. This manuscript describes a novel N-alkylated aromatic oligoamide proteomimetic scaffold and its solid-phase synthesis-the first time such an approach has been used for proteomimetics. The utility of these scaffolds as proteomimetics is exemplified through the identification of potent mu M inhibitors of the p53-hDM2 helix mediated PPI-a key oncogenic target.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available